5CYI
CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cyclin-dependent kinase 2 | polymer | 303 | 34467.9 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
2 | B, D | Cyclin-A2 | polymer | 260 | 29884.6 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (Human) | Cyclin-A |
3 | A, C | 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine | non-polymer | 415.5 | 2 | Chemie (55S) | |||
4 | water | water | 18.0 | 492 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 174 - 432 (UniProt: P20248)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Leu -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 173 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128705.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 831.0 | |
All* | Total formula weight | 129536.1 |