8VQ3

CDK2-CyclinE1 in complex with allosteric inhibitor I-198.

This is a non-PDB format compatible entry.

Summary for 8VQ3

• Entry DOI: 10.2210/pdb8vq3/pdb
• Related: 8VQ4
• Descriptor: Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, ... (4 entities in total)
• Functional Keywords: kinase, cell cycle-transferase-inhibitor complex, cell cycle/transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 67739.78

Authors

Hirschi, M.,Johnson, E.,Zhang, Y.,Liu, Z.,Brodsky, O.,Won, S.J.,Nagata, A.,Petroski, M.D.,Majmudar, J.D.,Niessen, S.,VanArsdale, T.,Gilbert, A.M.,Hayward, M.M.,Stewart, A.E.,Nager, A.R.,Melillo, B.,Cravatt, B. (deposition date: 2024-01-17, release date: 2024-01-31, Last modification date: 2024-02-14)

• Primary citation: Zhang, Y.,Liu, Z.,Hirschi, M.,Brodsky, O.,Johnson, E.,Won, S.J.,Nagata, A.,Petroski, M.D.,Majmudar, J.D.,Niessen, S.,VanArsdale, T.,Gilbert, A.M.,Hayward, M.M.,Stewart, A.E.,Nager, A.R.,Melillo, B.,Cravatt, B.; Expanding the ligandable proteome by paralog hopping with covalent probes.; Biorxiv, 2024; PubMed: 38293178; DOI: 10.1101/2024.01.18.576274

Experimental method

X-RAY DIFFRACTION (1.84 Å)