8VQ3
CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 2 | polymer | 298 | 34056.5 | 1 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B | G1/S-specific cyclin-E1 | polymer | 285 | 33053.5 | 1 | UniProt (P24864) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (human) | |
| 3 | A | (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide | non-polymer | 629.8 | 1 | Chemie (A1AC4) | |||
| 4 | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
B: 81 - 363 (UniProt: P24864)
| PDB | External Database | Details |
|---|---|---|
| Gly 79 | - | expression tag |
| Ser 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67110.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 629.8 | |
| All* | Total formula weight | 67739.8 |
