3F5X
CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site
Summary for 3F5X
Entry DOI | 10.2210/pdb3f5x/pdb |
Descriptor | Cell division protein kinase 2, Cyclin-A2, GLYCEROL, ... (6 entities in total) |
Functional Keywords | kinase, pkc, protein kinase, inhibitor, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, cyclin, nucleus, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P20248 |
Total number of polymer chains | 4 |
Total formula weight | 127936.36 |
Authors | Kiefer, J.R.,Day, J.E.,Caspers, N.L.,Mathis, K.J.,Kretzmer, K.K.,Weinberg, R.A.,Reitz, B.A.,Stegeman, R.A.,Trujillo, J.I.,Huang, W.,Thorarensen, A.,Xing, L.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. (deposition date: 2008-11-04, release date: 2009-02-03, Last modification date: 2023-12-27) |
Primary citation | Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Thorarensen, A.,Xing, L.,Caspers, N.L.,Day, J.E.,Mathis, K.J.,Kretzmer, K.K.,Reitz, B.A.,Weinberg, R.A.,Stegeman, R.A.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg.Med.Chem.Lett., 19:908-911, 2009 Cited by PubMed: 19097791DOI: 10.1016/j.bmcl.2008.11.105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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