5L2W
The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.
Summary for 5L2W
Entry DOI | 10.2210/pdb5l2w/pdb |
Related | 5L2I 5L2S 5L2T |
Descriptor | Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (5 entities in total) |
Functional Keywords | cyclin-dependent kinase, kinase inhibitor, kinase selectivity, transferase-cell cycle-inhibitor complex, transferase/cell cycle/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P24864 |
Total number of polymer chains | 2 |
Total formula weight | 70323.40 |
Authors | Chen, P.,Ferre, R.A.,Deihl, W.,Yu, X.,He, Y.-A. (deposition date: 2016-08-02, release date: 2016-08-24, Last modification date: 2023-10-04) |
Primary citation | Chen, P.,Lee, N.V.,Hu, W.,Xu, M.,Ferre, R.A.,Lam, H.,Bergqvist, S.,Solowiej, J.,Diehl, W.,He, Y.A.,Yu, X.,Nagata, A.,VanArsdale, T.,Murray, B.W. Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15:2273-2281, 2016 Cited by PubMed: 27496135DOI: 10.1158/1535-7163.MCT-16-0300 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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