5L2T

The X-ray co-crystal structure of human CDK6 and Ribociclib.

Summary for 5L2T

Entry DOI	10.2210/pdb5l2t/pdb
Related	5L2I 5L2S 5L2W
Descriptor	Cyclin-dependent kinase 6, 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (3 entities in total)
Functional Keywords	cyclin-dependent kinase, kinase inhibitor, kinase selectivity, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q00534
Total number of polymer chains	1
Total formula weight	35453.75
Authors	Chen, P.,Ferre, R.A.,Deihl, W.,Yu, X.,He, Y.-A. (deposition date: 2016-08-02, release date: 2016-08-24, Last modification date: 2024-03-06)
Primary citation	Chen, P.,Lee, N.V.,Hu, W.,Xu, M.,Ferre, R.A.,Lam, H.,Bergqvist, S.,Solowiej, J.,Diehl, W.,He, Y.A.,Yu, X.,Nagata, A.,VanArsdale, T.,Murray, B.W. Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15:2273-2281, 2016 Cited by PubMed: 27496135 DOI: 10.1158/1535-7163.MCT-16-0300 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation