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PDB: 357 件

7JVP
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Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
分子名称: (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E.
登録日2020-08-22
公開日2021-02-24
最終更新日2021-03-03
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 184, 2021
8GG0
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CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
7Y35
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Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
登録日2022-06-09
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
7RYC
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Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Meyerowitz, J.G, Robertson, M.J, Skiniotis, G.
登録日2021-08-24
公開日2022-03-09
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The oxytocin signaling complex reveals a molecular switch for cation dependence.
Nat.Struct.Mol.Biol., 29, 2022
8GW8
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the human PTH1 receptor bound to an intracellular biased agonist
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Kobayashi, K, Kusakizako, T, Okamoto, H.H, Nureki, O.
登録日2022-09-16
公開日2023-06-14
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Class B1 GPCR activation by an intracellular agonist.
Nature, 618, 2023
7F4F
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Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16
分子名称: Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E.
登録日2021-06-18
公開日2021-09-08
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Cell Res., 31, 2021
8WC8
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Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex
分子名称: 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日2023-09-11
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
7D3S
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Human SECR in complex with an engineered Gs heterotrimer
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Fukuhara, S, Kobayashi, K, Kusakizako, T, Shihoya, W, Nureki, O.
登録日2020-09-20
公開日2020-11-04
最終更新日2020-12-30
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
Biochem.Biophys.Res.Commun., 533, 2020
8XOG
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Cryo-EM structure of apo-GPR30-Gq complex structure
分子名称: G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Liu, H, Xu, P, Xu, H.E.
登録日2024-01-01
公開日2024-04-10
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
7E14
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Compound2_GLP-1R_OWL833_Gs complex structure
分子名称: 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, CHOLESTEROL, G protein, ...
著者Cong, Z.T, Chen, L.N, Ma, H.L, Yang, D.H, Xu, H.E, Zhang, Y, Wang, M.W.
登録日2021-01-30
公開日2021-07-07
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor.
Nat Commun, 12, 2021
7LCI
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PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
分子名称: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M.
登録日2021-01-11
公開日2021-01-20
最終更新日2021-09-15
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Evolving cryo-EM structural approaches for GPCR drug discovery.
Structure, 29, 2021
7CX4
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Cryo-EM structure of the Evatanepag-bound EP2-Gs complex
分子名称: 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y.
登録日2020-09-01
公開日2021-05-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.
Sci Adv, 7, 2021
6P9X
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CRF1 Receptor Gs GPCR protein complex with CRF1 peptide
分子名称: Corticoliberin, Corticotropin-releasing factor receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R.
登録日2019-06-10
公開日2020-02-05
最終更新日2020-02-19
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol.Cell, 77, 2020
8HMV
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Structure of GPR21-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Wong, T.S, Gao, W.
登録日2022-12-05
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Cryo-EM structure of orphan G protein-coupled receptor GPR21.
MedComm (2020), 4, 2023
8JIT
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Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GCGR-Gs complex
分子名称: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
登録日2023-05-27
公開日2023-09-06
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
8PM2
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Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein
分子名称: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Gusach, A, Lee, Y, Edwards, P.C, Huang, F, Weyand, S.N, Tate, C.G.
登録日2023-06-28
公開日2023-08-09
最終更新日2024-08-07
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.
Biorxiv, 2023
8FLR
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Human PTH1R in complex with PTHrP and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
7XW5
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TSHR-thyroid stimulating hormone-Gs-ML109 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ...
著者Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E.
登録日2022-05-26
公開日2022-08-24
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Hormone- and antibody-mediated activation of the thyrotropin receptor.
Nature, 609, 2022
8HTI
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Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein
分子名称: Consensus Olfactory Receptor OR52c, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Choi, C.W, Bae, J, Choi, H.-J, Kim, J.
登録日2022-12-21
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.
Nat Commun, 14, 2023
7AUE
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Melanocortin receptor 4 (MC4R) Gs protein complex
分子名称: AMINOSERINE, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Degtjarik, O, Israeli, H, Prabahar, V, Shalev-Benami, M.
登録日2020-11-02
公開日2021-04-28
最終更新日2023-03-15
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Science, 372, 2021
8IW7
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Cryo-EM structure of the PEA-bound mTAAR9-Gs complex
分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
登録日2023-03-29
公開日2023-05-31
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
7XY6
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Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM
分子名称: 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, J.Y, Chen, Y, Hua, T, Song, G.J.
登録日2022-05-31
公開日2023-05-03
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
7TYY
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Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYW
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Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
8JLR
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A77636-bound hTAAR1-Gs protein complex
分子名称: (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-02
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023

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件を2024-09-11に公開中

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