8JIT

Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GCGR-Gs complex

Summary for 8JIT

Entry DOI	10.2210/pdb8jit/pdb
EMDB information	36327
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, MEDI0382, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
Functional Keywords	g protein-coupled receptor, ligand recognition, receptor activation, unimolecular dual agonist, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	156992.19
Authors	Yang, L.,Zhou, Q.T.,Dai, A.T.,Zhao, F.H.,Chang, R.L.,Ying, T.L.,Wu, B.L.,Yang, D.H.,Wang, M.W.,Cong, Z.T. (deposition date: 2023-05-27, release date: 2023-09-06)
Primary citation	Li, Y.,Zhou, Q.,Dai, A.,Zhao, F.,Chang, R.,Ying, T.,Wu, B.,Yang, D.,Wang, M.W.,Cong, Z. Structural analysis of the dual agonism at GLP-1R and GCGR. Proc.Natl.Acad.Sci.USA, 120:e2303696120-e2303696120, 2023 Cited by PubMed: 37549266 DOI: 10.1073/pnas.2303696120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.91 Å)

Structure validation