7RYC

Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein

Summary for 7RYC

Entry DOI	10.2210/pdb7ryc/pdb
EMDB information	24733
Descriptor	Oxytocin, Oxytocin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywords	hormone, gpcr complex, transmembrane receptor, oxytocin receptor, otr, ot, oxtr, g protein, oxytocin, vasotocin, membrane protein, membrane protein-neuropeptide complex, membrane protein/neuropeptide
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	152682.05
Authors	Meyerowitz, J.G.,Robertson, M.J.,Skiniotis, G. (deposition date: 2021-08-24, release date: 2022-03-09, Last modification date: 2022-03-30)
Primary citation	Meyerowitz, J.G.,Robertson, M.J.,Barros-Alvarez, X.,Panova, O.,Nwokonko, R.M.,Gao, Y.,Skiniotis, G. The oxytocin signaling complex reveals a molecular switch for cation dependence. Nat.Struct.Mol.Biol., 29:274-281, 2022 Cited by PubMed: 35241813 DOI: 10.1038/s41594-022-00728-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation