7RYC

Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Oxytocin	polymer	10	1008.2	1	UniProt (P01178) Pfam (PF00220) In PDB	Homo sapiens
2	O	Oxytocin receptor	polymer	450	49627.1	1	UniProt (P30559) Pfam (PF00001) In PDB	Homo sapiens (human)	OT-R
3	D	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	326	36573.5	1	Pfam (PF00503) Pfam (PF00631) UniProt (by SIFTS) (P59768) UniProt (by SIFTS) (P04899) UniProt (by SIFTS) (P63092) In PDB	Homo sapiens (Human)
4	C	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	345	37728.2	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (human)	Transducin beta chain 1
5	E	scFv16	polymer	260	27720.8	1		Mus musculus
6	O	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

L: 1 - 9 (UniProt: P01178)

PDB	External Database	Details
Nh2 10	-	amidation

O: 1 - 389 (UniProt: P30559)

PDB	External Database	Details
Met -54	-	initiating methionine
Lys -53	-	expression tag
Thr -52	-	expression tag
Ile -51	-	expression tag
Ile -50	-	expression tag
Ala -49	-	expression tag
Leu -48	-	expression tag
Ser -47	-	expression tag
Tyr -46	-	expression tag
Ile -45	-	expression tag
Phe -44	-	expression tag
Cys -43	-	expression tag
Leu -42	-	expression tag
Val -41	-	expression tag
Phe -40	-	expression tag
Ala -39	-	expression tag
Asp -38	-	expression tag
Tyr -37	-	expression tag
Lys -36	-	expression tag
Asp -35	-	expression tag
Asp -34	-	expression tag
Asp -33	-	expression tag
Asp -32	-	expression tag
Ala -31	-	expression tag
Met -30	-	expression tag
Gly -29	-	expression tag
Gln -28	-	expression tag
Pro -27	-	expression tag
Gly -26	-	expression tag
Asn -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Ala -22	-	expression tag
Phe -21	-	expression tag
Leu -20	-	expression tag
Leu -19	-	expression tag
Ala -18	-	expression tag
Pro -17	-	expression tag
Asn -16	-	expression tag
Arg -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
Ala -12	-	expression tag
Pro -11	-	expression tag
Asp -10	-	expression tag
His -9	-	expression tag
Asp -8	-	expression tag
Val -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Leu 390	-	expression tag
Glu 391	-	expression tag
Val 392	-	expression tag
Leu 393	-	expression tag
Phe 394	-	expression tag
Gln 395	-	expression tag

D: 1 - 71 (PDB: 7RYC)
D: 992 - 1065 (PDB: 7RYC)
D: 1066 - 1246 (PDB: 7RYC)
C: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	152657.7
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	152682.1

*Water molecules are not included.