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7RYC

Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein

Functional Information from GO Data
ChainGOidnamespacecontents
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0019001molecular_functionguanyl nucleotide binding
D0031681molecular_functionG-protein beta-subunit binding
D0031683molecular_functionG-protein beta/gamma-subunit complex binding
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
L0005185molecular_functionneurohypophyseal hormone activity
L0005576cellular_componentextracellular region
O0001967biological_processsuckling behavior
O0001975biological_processresponse to amphetamine
O0001992biological_processregulation of systemic arterial blood pressure by vasopressin
O0004930molecular_functionG protein-coupled receptor activity
O0004990molecular_functionoxytocin receptor activity
O0005000molecular_functionvasopressin receptor activity
O0005886cellular_componentplasma membrane
O0005902cellular_componentmicrovillus
O0005912cellular_componentadherens junction
O0006936biological_processmuscle contraction
O0007166biological_processcell surface receptor signaling pathway
O0007186biological_processG protein-coupled receptor signaling pathway
O0007204biological_processpositive regulation of cytosolic calcium ion concentration
O0007507biological_processheart development
O0007565biological_processfemale pregnancy
O0007595biological_processlactation
O0007613biological_processmemory
O0009410biological_processresponse to xenobiotic stimulus
O0010701biological_processpositive regulation of norepinephrine secretion
O0014070biological_processresponse to organic cyclic compound
O0016020cellular_componentmembrane
O0016324cellular_componentapical plasma membrane
O0017046molecular_functionpeptide hormone binding
O0021537biological_processtelencephalon development
O0032230biological_processpositive regulation of synaptic transmission, GABAergic
O0032355biological_processresponse to estradiol
O0032570biological_processresponse to progesterone
O0032870biological_processcellular response to hormone stimulus
O0034059biological_processresponse to anoxia
O0034097biological_processresponse to cytokine
O0035176biological_processsocial behavior
O0042220biological_processresponse to cocaine
O0042277molecular_functionpeptide binding
O0042711biological_processmaternal behavior
O0042713biological_processsperm ejaculation
O0042755biological_processeating behavior
O0043434biological_processresponse to peptide hormone
O0044849biological_processestrous cycle
O0045777biological_processpositive regulation of blood pressure
O0045907biological_processpositive regulation of vasoconstriction
O0048545biological_processresponse to steroid hormone
O0048565biological_processdigestive tract development
O0051965biological_processpositive regulation of synapse assembly
O0051968biological_processpositive regulation of synaptic transmission, glutamatergic
O0060137biological_processmaternal process involved in parturition
O0060406biological_processpositive regulation of penile erection
O0070371biological_processERK1 and ERK2 cascade
O0070474biological_processpositive regulation of uterine smooth muscle contraction
O0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASTyLLLLMSLDRCLaI
ChainResidueDetails
OALA125-ILE141

site_idPS00264
Number of Residues9
DetailsNEUROHYPOPHYS_HORM Neurohypophysial hormones signature. CYIqNCPlG
ChainResidueDetails
LCYS1-GLY9

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
DALA2
OLEU98-ARG113
OSER176-THR202
OGLN295-SER309

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
OASP136-ARG154
OLYS226-LYS275
OTHR333-ALA389

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P63096
ChainResidueDetails
DGLY1040

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
DSER1047
DALA1176
DGLU1182

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
DGLU1179

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:22223895, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
DGLY1002

site_idSWS_FT_FI8
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
DSER1003

site_idSWS_FT_FI9
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
DASP1085
DLEU1154
DALA1218

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
DSER1204
OSER368

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
DASP1162
OASN15
OASN26

222926

PDB entries from 2024-07-24

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