7F4F

Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16

Summary for 7F4F

• Entry DOI: 10.2210/pdb7f4f/pdb
• EMDB information: 31448 31449 31452 31453
• Descriptor: scFv16, Melanocortin-1 receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (7 entities in total)
• Functional Keywords: g protein-coupled receptors, mc1r, melanocyte, clacium ion, activation, membrane protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 6
• Total formula weight: 190149.57

Authors

Ma, S.,Chen, Y.,Dai, A.,Yin, W.,Guo, J.,Yang, D.,Zhou, F.,Jiang, Y.,Wang, M.-W.,Xu, H.E. (deposition date: 2021-06-18, release date: 2021-09-08, Last modification date: 2022-02-16)

• Primary citation: Ma, S.,Chen, Y.,Dai, A.,Yin, W.,Guo, J.,Yang, D.,Zhou, F.,Jiang, Y.,Wang, M.W.,Xu, H.E.; Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.; Cell Res., 31:1061-1071, 2021; PubMed: 34453129; DOI: 10.1038/s41422-021-00557-y

Experimental method

ELECTRON MICROSCOPY (2.9 Å)