8GW8

the human PTH1 receptor bound to an intracellular biased agonist

Summary for 8GW8

Entry DOI	10.2210/pdb8gw8/pdb
EMDB information	34305
Descriptor	Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	g protein-coupled receptor, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	157151.08
Authors	Kobayashi, K.,Kusakizako, T.,Okamoto, H.H.,Nureki, O. (deposition date: 2022-09-16, release date: 2023-06-14, Last modification date: 2023-09-27)
Primary citation	Kobayashi, K.,Kawakami, K.,Kusakizako, T.,Tomita, A.,Nishimura, M.,Sawada, K.,Okamoto, H.H.,Hiratsuka, S.,Nakamura, G.,Kuwabara, R.,Noda, H.,Muramatsu, H.,Shimizu, M.,Taguchi, T.,Inoue, A.,Murata, T.,Nureki, O. Class B1 GPCR activation by an intracellular agonist. Nature, 618:1085-1093, 2023 Cited by PubMed: 37286611 DOI: 10.1038/s41586-023-06169-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation