8FLR

Human PTH1R in complex with PTHrP and Gs

Summary for 8FLR

• Entry DOI: 10.2210/pdb8flr/pdb
• EMDB information: 29283 29284 29285 29286 29287
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, agonist, hormone, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 177141.73

Authors

Cary, B.P.,Belousoff, M.J.,Piper, S.J.,Wootten, D.,Sexton, P.M. (deposition date: 2022-12-22, release date: 2023-04-26, Last modification date: 2023-06-14)

• Primary citation: Cary, B.P.,Gerrard, E.J.,Belousoff, M.J.,Fletcher, M.M.,Jiang, Y.,Russell, I.C.,Piper, S.J.,Wootten, D.,Sexton, P.M.; Molecular insights into peptide agonist engagement with the PTH receptor.; Structure, 31:668-676.e5, 2023; PubMed: 37148874; DOI: 10.1016/j.str.2023.04.002

Experimental method

ELECTRON MICROSCOPY (2.94 Å)