8FLR
Human PTH1R in complex with PTHrP and Gs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37413.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 58 | 6375.3 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody35 | polymer | 128 | 13885.4 | 1 | Lama glama (llama) | ||
5 | P | PTHrP[1-36] | polymer | 36 | 4269.9 | 1 | UniProt (P12272) Pfam (PF01279) In PDB | Homo sapiens | |
6 | R | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 616 | 69513.8 | 1 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
7 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 28 - 593 (UniProt: Q03431)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | engineered mutation |
Ala 226 | Gly 226 | engineered mutation |
Ala 268 | Glu 268 | engineered mutation |
Lys 271 | Asn 271 | engineered mutation |
Asp 274 | Lys 274 | engineered mutation |
Lys 280 | Arg 280 | engineered mutation |
Asp 284 | Thr 284 | engineered mutation |
Thr 285 | Ile 285 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -3 | - | expression tag |
Lys -2 | - | expression tag |
Thr -1 | - | expression tag |
Ile 0 | - | expression tag |
Ile 1 | - | expression tag |
Ala 2 | - | expression tag |
Leu 3 | - | expression tag |
Ser 4 | - | expression tag |
Tyr 5 | - | expression tag |
Ile 6 | - | expression tag |
Phe 7 | - | expression tag |
Cys 8 | - | expression tag |
Leu 9 | - | expression tag |
Val 10 | - | expression tag |
Phe 11 | - | expression tag |
Ala 12 | - | expression tag |
Asp 13 | - | expression tag |
Tyr 14 | - | expression tag |
Lys 15 | - | expression tag |
Asp 16 | - | expression tag |
Asp 17 | - | expression tag |
Asp 18 | - | expression tag |
Asp 19 | - | expression tag |
Leu 20 | - | expression tag |
Glu 21 | - | expression tag |
Val 22 | - | expression tag |
Leu 23 | - | expression tag |
Phe 24 | - | expression tag |
Gln 25 | - | expression tag |
Gly 26 | - | expression tag |
Pro 27 | - | expression tag |
Pro 594 | - | expression tag |
Ala 595 | - | expression tag |
Gly 596 | - | expression tag |
Leu 597 | - | expression tag |
Glu 598 | - | expression tag |
Val 599 | - | expression tag |
Leu 600 | - | expression tag |
Phe 601 | - | expression tag |
Gln 602 | - | expression tag |
Gly 603 | - | expression tag |
Pro 604 | - | expression tag |
His 605 | - | expression tag |
His 606 | - | expression tag |
His 607 | - | expression tag |
His 608 | - | expression tag |
His 609 | - | expression tag |
His 610 | - | expression tag |
His 611 | - | expression tag |
His 612 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 177141.7 | |
All* | Total formula weight | 177141.7 |