7CX4
Cryo-EM structure of the Evatanepag-bound EP2-Gs complex
Summary for 7CX4
Entry DOI | 10.2210/pdb7cx4/pdb |
EMDB information | 30491 |
Descriptor | Prostaglandin E2 receptor EP2 subtype, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | gpcr, ep2, complex, evatanepag, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 147188.17 |
Authors | |
Primary citation | Qu, C.,Mao, C.,Xiao, P.,Shen, Q.,Zhong, Y.N.,Yang, F.,Shen, D.D.,Tao, X.,Zhang, H.,Yan, X.,Zhao, R.J.,He, J.,Guan, Y.,Zhang, C.,Hou, G.,Zhang, P.J.,Hou, G.,Li, Z.,Yu, X.,Chai, R.J.,Guan, Y.F.,Sun, J.P.,Zhang, Y. Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype. Sci Adv, 7:-, 2021 Cited by PubMed: 33811074DOI: 10.1126/sciadv.abf1268 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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