7XW5
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Summary for 7XW5
Entry DOI | 10.2210/pdb7xw5/pdb |
EMDB information | 33491 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, CHOLESTEROL, PALMITIC ACID, ... (11 entities in total) |
Functional Keywords | thyroid-stimulating hormone, thyroid-stimulating hormone receptor, ths, thsr, gpcr, gs, ml-109, membrane protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 7 |
Total formula weight | 202682.14 |
Authors | |
Primary citation | Duan, J.,Xu, P.,Luan, X.,Ji, Y.,He, X.,Song, N.,Yuan, Q.,Jin, Y.,Cheng, X.,Jiang, H.,Zheng, J.,Zhang, S.,Jiang, Y.,Xu, H.E. Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609:854-859, 2022 Cited by PubMed: 35940204DOI: 10.1038/s41586-022-05173-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.96 Å) |
Structure validation
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