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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7XW5

TSHR-thyroid stimulating hormone-Gs-ML109 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer24929068.91UniProt (P63094)
Pfam (PF00503)
UniProt (by SIFTS) (P63092)		Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35038613.21UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(N)		Nanobody35polymer13414714.31Lama glama
5E
(R)		Thyrotropin receptorpolymer70279920.81UniProt (P16473)
Pfam (PF13306)
Pfam (PF00001)		Homo sapiens (human)Thyroid-stimulating hormone receptor,TSH-R
6F
(X)		Glycoprotein hormones alpha chainpolymer9210217.81UniProt (P01215)
Pfam (PF00236)		Homo sapiens (human)Anterior pituitary glycoprotein hormones common subunit alpha,Choriogonadotropin alpha chain,Chorionic gonadotrophin subunit alpha,CG-alpha,Follicle-stimulating hormone alpha chain,FSH-alpha,Follitropin alpha chain,Luteinizing hormone alpha chain,LSH-alpha,Lutropin alpha chain,Thyroid-stimulating hormone alpha chain,TSH-alpha,Thyrotropin alpha chain
7G
(Y)		Thyrotropin subunit betapolymer11813518.71UniProt (P01222)
Pfam (PF00007)		Homo sapiens (human)Thyroid-stimulating hormone subunit beta,TSH-B,TSH-beta,Thyrotropin beta chain
8FA, GA, H, HA, I...
(X, R, Y)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.27Chemie (NAG)
9L
(R)		~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamidenon-polymer523.61Chemie (HOI)
PubChem (25246343)
PubChem (118685720)
10M, N, O, P, Q...
(R)		CHOLESTEROLnon-polymer386.714Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
11AA, BA, CA, DA, EA
(R)		PALMITIC ACIDnon-polymer256.45Chemie (PLM)
Sequence modifications
A: 5 - 203 (PDB: 7XW5)
A: 204 - 384 (UniProt: P63094)
PDBExternal DatabaseDetails
Ala 226Gly 226conflict
Asp 249Ala 249conflict
Asp 252Ser 252conflict
-Met 255deletion
-Val 256deletion
-Ile 257deletion
-Arg 258deletion
-Glu 259deletion
-Asp 260deletion
-Asn 261deletion
-Gln 262deletion
-Thr 263deletion
-Asn 264deletion
Ser 356Ala 366conflict
Ala 362Ile 372conflict
Ile 365Val 375conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: 21 - 764 (UniProt: P16473)
PDBExternal DatabaseDetails
Ile 281Ser 281variant
-Ala 317deletion
-Leu 318deletion
-Asn 319deletion
-Ser 320deletion
-Pro 321deletion
-Leu 322deletion
-His 323deletion
-Gln 324deletion
-Glu 325deletion
-Tyr 326deletion
-Glu 327deletion
-Glu 328deletion
-Asn 329deletion
-Leu 330deletion
-Gly 331deletion
-Asp 332deletion
-Ser 333deletion
-Ile 334deletion
-Val 335deletion
-Gly 336deletion
-Tyr 337deletion
-Lys 338deletion
-Glu 339deletion
-Lys 340deletion
-Ser 341deletion
-Lys 342deletion
-Phe 343deletion
-Gln 344deletion
-Asp 345deletion
-Thr 346deletion
-His 347deletion
-Asn 348deletion
-Asn 349deletion
-Ala 350deletion
-His 351deletion
-Tyr 352deletion
-Tyr 353deletion
-Val 354deletion
-Phe 355deletion
-Phe 356deletion
-Glu 357deletion
-Glu 358deletion
-Gln 359deletion
-Glu 360deletion
-Asp 361deletion
-Glu 362deletion
-Ile 363deletion
-Ile 364deletion
-Gly 365deletion
-Phe 366deletion
Asn 367Gly 367conflict
Lys 368Gln 368conflict
Thr 369Glu 369conflict
His 765-expression tag
His 766-expression tag
His 767-expression tag
His 768-expression tag
His 769-expression tag
His 770-expression tag
His 771-expression tag
His 772-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight193914.8
Non-Polymers*Number of molecules27
Total formula weight8767.3
All*Total formula weight202682.1
*Water molecules are not included.

253389

PDB entries from 2026-05-13

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