5XDK
| Crystal structure of EGFR 696-1022 T790M in complex with CO-1686 | Descriptor: | Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2017-03-28 | Release date: | 2017-12-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.346 Å) | Cite: | Structural basis of mutant-selectivity and drug-resistance related to CO-1686. Oncotarget, 8, 2017
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5OPX
| Crystal structure of the GroEL mutant A109C in complex with GroES and ADP BeF2 | Descriptor: | 10 kDa chaperonin, 60 kDa chaperonin, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Yan, X, Shi, Q, Bracher, A, Milicic, G, Singh, A.K, Hartl, F.U, Hayer-Hartl, M. | Deposit date: | 2017-08-10 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | GroEL Ring Separation and Exchange in the Chaperonin Reaction. Cell, 172, 2018
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5OPW
| Crystal structure of the GroEL mutant A109C | Descriptor: | 60 kDa chaperonin | Authors: | Yan, X, Shi, Q, Bracher, A, Milicic, G, Singh, A.K, Hartl, F.U, Hayer-Hartl, M. | Deposit date: | 2017-08-10 | Release date: | 2018-01-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | GroEL Ring Separation and Exchange in the Chaperonin Reaction. Cell, 172, 2018
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2QHA
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7YLL
| Crystal structure of TTEDbh | Descriptor: | DNA polymerase IV, MAGNESIUM ION, PHOSPHATE ION | Authors: | Yan, X, Tian, L, Gao, H. | Deposit date: | 2022-07-26 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.6000092 Å) | Cite: | Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis. Int.J.Biol.Macromol., 253, 2023
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5K5X
| Crystal structure of human PDGFRA | Descriptor: | Platelet-derived growth factor receptor alpha, SULFATE ION | Authors: | Yan, X.E, Liang, L, Yun, C.H. | Deposit date: | 2016-05-24 | Release date: | 2016-08-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.168 Å) | Cite: | Structural and biochemical studies of the PDGFRA kinase domain Biochem.Biophys.Res.Commun., 477, 2016
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4AIA
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4ZSE
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4I0N
| Pore forming protein | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Necrotic enteritis toxin B | Authors: | Yan, X, Porter, C.J, Hardy, S.P, Steer, D, Smith, A.I, Quinset, N, Hughes, V, Cheung, J.K, Keyburn, A.L, Kaldhusdal, M, Moore, R.J, Bannam, T.L, Whisstock, J.C, Rood, J.I. | Deposit date: | 2012-11-16 | Release date: | 2013-03-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and functional analysis of the pore-forming toxin NetB from Clostridium perfringens MBio, 4, 2013
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6XKC
| Crystal structure of E3 ligase | Descriptor: | Protein fem-1 homolog C | Authors: | Yan, X, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Dong, C, Structural Genomics Consortium (SGC) | Deposit date: | 2020-06-26 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Molecular basis for ubiquitin ligase CRL2 FEM1C -mediated recognition of C-degron. Nat.Chem.Biol., 17, 2021
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5Y4R
| Structure of a methyltransferase complex | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Chemotaxis protein methyltransferase 1, Cyclic diguanosine monophosphate-binding protein PA4608, ... | Authors: | Yan, X, Xin, L, Tan, Y.J, Jin, S, Liang, Z.X, Gao, Y.G. | Deposit date: | 2017-08-04 | Release date: | 2017-11-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein. J. Biol. Chem., 293, 2018
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5GMP
| Crystal structure of EGFR 696-1022 T790M in complex with XTF-262 | Descriptor: | Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-07-14 | Release date: | 2017-06-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.797 Å) | Cite: | A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. Eur J Med Chem, 126, 2017
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5GNK
| Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34 | Descriptor: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, CHLORIDE ION, ... | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-07-21 | Release date: | 2017-04-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. J. Med. Chem., 60, 2017
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5GTY
| Crystal structure of EGFR 696-1022 T790M in complex with LXX-6-26 | Descriptor: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, Epidermal growth factor receptor | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-08-23 | Release date: | 2017-09-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget, 8, 2017
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5Y4S
| Structure of a methyltransferase complex | Descriptor: | Chemotaxis protein methyltransferase 1 | Authors: | Yan, X, Xin, L, Tan, Y.J, Jin, S, Liang, Z.X, Gao, Y.G. | Deposit date: | 2017-08-04 | Release date: | 2017-11-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.405 Å) | Cite: | Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein. J. Biol. Chem., 293, 2018
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5GRN
| Crystal structure of PDGFRA in Complex with WQ-C-159 | Descriptor: | CHLORIDE ION, N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide, Platelet-derived growth factor receptor alpha | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2016-08-11 | Release date: | 2017-08-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal Structure of PDGFRA in Complex with WQ-C-159 To Be Published
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5GTZ
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4QND
| Crystal structure of a SemiSWEET | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Chemical transport protein, ... | Authors: | Yan, X, Yuyong, T, Liang, F, Perry, K. | Deposit date: | 2014-06-17 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature, 515, 2014
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7YFJ
| Crystal structure of human WTAP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Pre-mRNA-splicing regulator WTAP | Authors: | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | Deposit date: | 2022-07-08 | Release date: | 2023-01-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | AI-empowered integrative structural characterization of m 6 A methyltransferase complex. Cell Res., 32, 2022
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4QNC
| Crystal structure of a SemiSWEET in an occluded state | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PENTADECANE, chemical transport protein | Authors: | Yan, X, Yuyong, T, Liang, F, Perry, K. | Deposit date: | 2014-06-17 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.388 Å) | Cite: | Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature, 515, 2014
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8YSB
| Crystal structure of DynA1, a putative monoxygenase from Mivromonospora chersina. | Descriptor: | Predicted ester cyclase | Authors: | Yan, X.F, Huang, H.W, Gao, Y.G, Liang, Z.X. | Deposit date: | 2024-03-22 | Release date: | 2024-09-04 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | An Enzymatic Oxidation Cascade Converts delta-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes. Jacs Au, 4, 2024
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7YG4
| Structure of WTAP-VIRMA in the m6A writer complex | Descriptor: | Pre-mRNA-splicing regulator WTAP, Protein virilizer homolog | Authors: | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | Deposit date: | 2022-07-11 | Release date: | 2022-11-23 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | AI-empowered integrative structural characterization of m 6 A methyltransferase complex. Cell Res., 32, 2022
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5YU9
| Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib | Descriptor: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, Epidermal growth factor receptor | Authors: | Yan, X.E, Yun, C.H. | Deposit date: | 2017-11-21 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation. Oncotarget, 7, 2016
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8H5Z
| Crystal structure of RadD/ATP analogue complex | Descriptor: | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative DNA repair helicase RadD, ZINC ION | Authors: | Yan, X.X, Tian, L.F. | Deposit date: | 2022-10-14 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.00002718 Å) | Cite: | Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli. Int J Mol Sci, 24, 2023
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8H5Y
| Crystal structure of RadD- ADP complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative DNA repair helicase RadD, ... | Authors: | Yan, X.X, Tian, L.F. | Deposit date: | 2022-10-14 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7001 Å) | Cite: | Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli. Int J Mol Sci, 24, 2023
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