5GTZ

Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39

Summary for 5GTZ

• Entry DOI: 10.2210/pdb5gtz/pdb
• Related: 5GMP 5GNK 5GTY
• Descriptor: Epidermal growth factor receptor, N-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: egfr, t790m, jts-1-39, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38690.29

Authors

Yan, X.E.,Yun, C.H. (deposition date: 2016-08-24, release date: 2017-09-06, Last modification date: 2024-10-23)

• Primary citation: Yan, X.E.,Yun, C.H.; Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.999 Å)