5GTZ
Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 37650.6 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | N-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide | non-polymer | 614.2 | 1 | Chemie (81C) | |||
| 3 | C, D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | G, H, I, J, K (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | L (A) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ala 693 | - | expression tag |
| Met 694 | - | expression tag |
| Gly 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37650.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1039.7 | |
| All* | Total formula weight | 38690.3 |
