5XDK
Crystal structure of EGFR 696-1022 T790M in complex with CO-1686
Summary for 5XDK
Entry DOI | 10.2210/pdb5xdk/pdb |
Related | 5XDL |
Descriptor | Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide (3 entities in total) |
Functional Keywords | egfr, t790m, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38206.15 |
Authors | |
Primary citation | Yan, X.E.,Zhu, S.J.,Liang, L.,Zhao, P.,Choi, H.G.,Yun, C.H. Structural basis of mutant-selectivity and drug-resistance related to CO-1686. Oncotarget, 8:53508-53517, 2017 Cited by PubMed: 28881827DOI: 10.18632/oncotarget.18588 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.346 Å) |
Structure validation
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