5GMP

Crystal structure of EGFR 696-1022 T790M in complex with XTF-262

Summary for 5GMP

Entry DOI	10.2210/pdb5gmp/pdb
Descriptor	Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide (3 entities in total)
Functional Keywords	egfr, t790m, xtf-262, inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38176.20
Authors	Yan, X.E.,Yun, C.H. (deposition date: 2016-07-14, release date: 2017-06-28, Last modification date: 2023-11-08)
Primary citation	Yu, L.,Huang, M.,Xu, T.,Tong, L.,Yan, X.E.,Zhang, Z.,Xu, Y.,Yun, C.,Xie, H.,Ding, K.,Lu, X. A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. Eur J Med Chem, 126:1107-1117, 2017 Cited by PubMed: 28033579 DOI: 10.1016/j.ejmech.2016.12.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.797 Å)

Structure validation