1KLC
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![BU of 1klc by Molmil](/molmil-images/mine/1klc) | SOLUTION STRUCTURE OF TGF-B1, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | TRANSFORMING GROWTH FACTOR-BETA 1 | Authors: | Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. | Deposit date: | 1996-01-16 | Release date: | 1996-08-17 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
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1KLD
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![BU of 1kld by Molmil](/molmil-images/mine/1kld) | SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 18-33 OF 33 STRUCTURES | Descriptor: | TRANSFORMING GROWTH FACTOR-BETA 1 | Authors: | Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. | Deposit date: | 1996-01-16 | Release date: | 1996-08-17 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
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2QCQ
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![BU of 2qcq by Molmil](/molmil-images/mine/2qcq) | |
2QCW
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![BU of 2qcw by Molmil](/molmil-images/mine/2qcw) | |
2R52
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![BU of 2r52 by Molmil](/molmil-images/mine/2r52) | |
2TGI
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![BU of 2tgi by Molmil](/molmil-images/mine/2tgi) | |
2R53
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![BU of 2r53 by Molmil](/molmil-images/mine/2r53) | |
3KFD
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4UX8
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![BU of 4ux8 by Molmil](/molmil-images/mine/4ux8) | RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ... | Authors: | Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q. | Deposit date: | 2014-08-19 | Release date: | 2014-10-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association. Cell Rep., 8, 2014
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7AG0
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![BU of 7ag0 by Molmil](/molmil-images/mine/7ag0) | Complex between the bone morphogenetic protein 2 and its antagonist Noggin | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Noggin | Authors: | Robert, C, Bruck, F, Herman, R, Vandevenne, M, Filee, P, Kerff, F, Matagne, A. | Deposit date: | 2020-09-21 | Release date: | 2022-04-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.104 Å) | Cite: | Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. J.Biol.Chem., 299, 2023
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6Q2R
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![BU of 6q2r by Molmil](/molmil-images/mine/6q2r) | Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ... | Authors: | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | Deposit date: | 2019-08-08 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife, 8, 2019
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3EVS
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![BU of 3evs by Molmil](/molmil-images/mine/3evs) | Crystal structure of the GDF-5:BMP receptor IB complex. | Descriptor: | Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 | Authors: | Kotzsch, A, Mueller, T.D. | Deposit date: | 2008-10-13 | Release date: | 2009-03-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28, 2009
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3SEK
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![BU of 3sek by Molmil](/molmil-images/mine/3sek) | Crystal Structure of the Myostatin:Follistatin-like 3 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 | Authors: | Cash, J.N, Thompson, T.B. | Deposit date: | 2011-06-10 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J.Biol.Chem., 287, 2012
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7MRZ
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![BU of 7mrz by Molmil](/molmil-images/mine/7mrz) | Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... | Authors: | Goebel, E.J, Kattamuri, C, Gipson, G.R, Thompson, T.B. | Deposit date: | 2021-05-10 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
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4FAO
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![BU of 4fao by Molmil](/molmil-images/mine/4fao) | Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... | Authors: | Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. | Deposit date: | 2012-05-22 | Release date: | 2012-06-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.357 Å) | Cite: | Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287, 2012
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8OS6
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![BU of 8os6 by Molmil](/molmil-images/mine/8os6) | Structure of a GFRA1/GDNF LICAM complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Houghton, F.M, Adams, S.E, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2023-04-18 | Release date: | 2023-11-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Architecture and regulation of a GDNF-GFR alpha 1 synaptic adhesion assembly. Nat Commun, 14, 2023
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6MAC
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![BU of 6mac by Molmil](/molmil-images/mine/6mac) | Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 11, ... | Authors: | Goebel, E.J, Thompson, T.B. | Deposit date: | 2018-08-27 | Release date: | 2019-07-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UJA
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![BU of 6uja by Molmil](/molmil-images/mine/6uja) | Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | Deposit date: | 2019-10-02 | Release date: | 2020-02-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
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6UMX
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![BU of 6umx by Molmil](/molmil-images/mine/6umx) | Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | Descriptor: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | Authors: | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | Deposit date: | 2019-10-10 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015. J.Biol.Chem., 295, 2020
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8DC0
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3QB4
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3FUB
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![BU of 3fub by Molmil](/molmil-images/mine/3fub) | Crystal structure of GDNF-GFRalpha1 complex | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Parkash, V, Goldman, A. | Deposit date: | 2009-01-14 | Release date: | 2009-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling Acta Crystallogr.,Sect.F, 65, 2009
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8FXV
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![BU of 8fxv by Molmil](/molmil-images/mine/8fxv) | Crystal structure of human proTGF-beta2 in complex with Nb18 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 18, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FXS
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![BU of 8fxs by Molmil](/molmil-images/mine/8fxs) | Crystal structure of human pro-TGF-beta2 in complex with Nb9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 9, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
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7U5O
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![BU of 7u5o by Molmil](/molmil-images/mine/7u5o) | CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B | Descriptor: | Bone morphogenetic protein receptor type-2, Inhibin beta B chain | Authors: | Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E. | Deposit date: | 2022-03-02 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. J.Biol.Chem., 298, 2022
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