6Q2R

Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form

Summary for 6Q2R

• Entry DOI: 10.2210/pdb6q2r/pdb
• EMDB information: 20576 20577 20578
• Descriptor: Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret, ... (5 entities in total)
• Functional Keywords: ret, receptor tyrosine kinase, cryo-em, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 487469.64

Authors

Li, J.,Shang, G.J.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.W.,Bai, X.C. (deposition date: 2019-08-08, release date: 2019-10-02, Last modification date: 2020-07-29)

• Primary citation: Li, J.,Shang, G.,Chen, Y.J.,Brautigam, C.A.,Liou, J.,Zhang, X.,Bai, X.C.; Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.; Elife, 8:-, 2019; PubMed: 31535977; DOI: 10.7554/eLife.47650

Experimental method

ELECTRON MICROSCOPY (4.3 Å)