6Q2R
Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, U, V | Neurturin | polymer | 102 | 11706.4 | 4 | UniProt (Q99748) Pfam (PF00019) In PDB | Homo sapiens (Human) | |
2 | C, D, W, X | GDNF family receptor alpha-2 | polymer | 349 | 39572.6 | 4 | UniProt (O00451) Pfam (PF02351) In PDB | Homo sapiens (Human) | GFR-alpha-2,GDNF receptor beta,GDNFR-beta,Neurturin receptor alpha,NTNR-alpha,RET ligand 2,TGF-beta-related neurotrophic factor receptor 2 |
3 | E, F, Y, Z | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 617 | 69100.8 | 4 | UniProt (P07949) Pfam (PF17756) Pfam (PF00028) Pfam (PF17812) Pfam (PF17813) Pfam (PF22540) In PDB | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
4 | Y, E, Z, F | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) | |||
5 | F, Y, E, Z | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 24 | Chemie (NAG) |
Sequence modifications
C, D, W, X: 24 - 362 (UniProt: O00451)
E, F, Y, Z: 29 - 635 (UniProt: P07949)
PDB | External Database | Details |
---|---|---|
Gly 363 | - | expression tag |
Thr 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
His 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 114 | Arg 114 | conflict |
Gly 636 | - | expression tag |
Thr 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
His 642 | - | expression tag |
His 643 | - | expression tag |
His 644 | - | expression tag |
His 645 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 481519.4 | |
Non-Polymers* | Number of molecules | 40 |
Total formula weight | 5950.2 | |
All* | Total formula weight | 487469.6 |