3KFD

Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily

Summary for 3KFD

• Entry DOI: 10.2210/pdb3kfd/pdb
• Related: 1M9Z 1REW 1TGJ 1TGK 2PJY 2TGI
• Descriptor: Transforming growth factor beta-1, TGF-beta receptor type-2, TGF-beta receptor type-1, ... (4 entities in total)
• Functional Keywords: tgf-beta, tgf-b1, tgf-beta receptor type-1, tgf-beta receptor type-2, tbrii, tbri, growth factor, receptor, serine/threonine-protein kinase, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space, extracellular matrix: P01137; Membrane; Single-pass type I membrane protein: P37173 P36897
• Total number of polymer chains: 12
• Total formula weight: 141462.20

Authors

Radaev, S.,Sun, P.D. (deposition date: 2009-10-27, release date: 2010-03-02, Last modification date: 2023-09-06)

• Primary citation: Radaev, S.,Zou, Z.,Huang, T.,Lafer, E.M.,Hinck, A.P.,Sun, P.D.; Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.; J.Biol.Chem., 285:14806-14814, 2010; PubMed: 20207738; DOI: 10.1074/jbc.M109.079921

Experimental method

X-RAY DIFFRACTION (2.995 Å)