2PJY
Structural basis for cooperative assembly of the TGF-beta signaling complex
Summary for 2PJY
Entry DOI | 10.2210/pdb2pjy/pdb |
Descriptor | Transforming growth factor beta-3, TGF-beta receptor type-2, TGF-beta receptor type-1, ... (4 entities in total) |
Functional Keywords | ternary complex, three finger toxin, cytokine-cytokine receptor complex, cytokine/cytokine receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P10600 Membrane; Single-pass type I membrane protein: P37173 P36897 |
Total number of polymer chains | 3 |
Total formula weight | 33694.56 |
Authors | Groppe, J.,Zubieta, C. (deposition date: 2007-04-16, release date: 2008-02-05, Last modification date: 2023-08-30) |
Primary citation | Groppe, J.,Hinck, C.S.,Samavarchi-Tehrani, P.,Zubieta, C.,Schuermann, J.P.,Taylor, A.B.,Schwarz, P.M.,Wrana, J.L.,Hinck, A.P. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol.Cell, 29:157-168, 2008 Cited by PubMed: 18243111DOI: 10.1016/j.molcel.2007.11.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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