2PJY
Structural basis for cooperative assembly of the TGF-beta signaling complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transforming growth factor beta-3 | polymer | 112 | 12734.5 | 1 | UniProt (P10600) Pfam (PF00019) | Homo sapiens (human) | TGF-beta-3 |
| 2 | B (B) | TGF-beta receptor type-2 | polymer | 108 | 12244.1 | 1 | UniProt (P37173) Pfam (PF08917) | Homo sapiens (human) | TGF-beta receptor type II, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II |
| 3 | C (C) | TGF-beta receptor type-1 | polymer | 79 | 8715.9 | 1 | UniProt (P36897) Pfam (PF01064) | Homo sapiens (human) | TGF-beta receptor type I, TGFR-1, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TbetaR-I, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5 |
| 4 | D, E (B, C) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
B: 19 - 126 (UniProt: P37173)
C: 9 - 87 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Ala 19 | Asn 42 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 46 | Met 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33694.6 | |
| All* | Total formula weight | 33694.6 |
