3QB4

Crystal structure of a TGF-beta ligand-receptor complex

Summary for 3QB4

Entry DOI	10.2210/pdb3qb4/pdb
Related	1REW 1WAQ 2K3G 3EVS 3NH7
Descriptor	Growth/differentiation factor 5, Bone morphogenetic protein receptor type-1A (3 entities in total)
Functional Keywords	cystine-knot, ligand-receptor complex, protein, membrane/extracellular, cytokine-transferase receptor complex, cytokine/transferase receptor
Biological source	Homo sapiens (human) More
Cellular location	Secreted : P43026 Membrane; Single-pass type I membrane protein: P36894
Total number of polymer chains	4
Total formula weight	55987.63
Authors	Mueller, T.D.,Nickel, J.,Sebald, W. (deposition date: 2011-01-12, release date: 2012-03-14, Last modification date: 2023-09-13)
Primary citation	Klammert, U.,Mueller, T.D.,Hellmann, T.V.,Wuerzler, K.K.,Kotzsch, A.,Schliermann, A.,Schmitz, W.,Kuebler, A.C.,Sebald, W.,Nickel, J. GDF-5 can act as a context-dependent BMP-2 antagonist. Bmc Biol., 13:77-77, 2015 Cited by PubMed: 26385096 DOI: 10.1186/s12915-015-0183-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation