3QB4
Crystal structure of a TGF-beta ligand-receptor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Growth/differentiation factor 5 | polymer | 117 | 13319.4 | 2 | UniProt (P43026) Pfam (PF00019) | Homo sapiens (human) | GDF-5, Cartilage-derived morphogenetic protein 1, CDMP-1, Radotermin |
| 2 | B, D (B, D) | Bone morphogenetic protein receptor type-1A | polymer | 135 | 14674.5 | 2 | UniProt (P36894) Pfam (PF01064) | Homo sapiens (human) | BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5 |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A, C: 6 - 120 (UniProt: P43026)
B, D: 1 - 129 (UniProt: P36894)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | - | expression tag |
| Lys 5 | - | expression tag |
| Ala 57 | Arg 438 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55987.6 | |
| All* | Total formula weight | 55987.6 |
