3QB4
Crystal structure of a TGF-beta ligand-receptor complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Growth/differentiation factor 5 | polymer | 117 | 13319.4 | 2 | UniProt (P43026) Pfam (PF00019) In PDB | Homo sapiens (human) | GDF-5, Cartilage-derived morphogenetic protein 1, CDMP-1, Radotermin |
2 | B, D | Bone morphogenetic protein receptor type-1A | polymer | 135 | 14674.5 | 2 | UniProt (P36894) Pfam (PF01064) In PDB | Homo sapiens (human) | BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5 |
3 | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A, C: 6 - 120 (UniProt: P43026)
B, D: 1 - 129 (UniProt: P36894)
PDB | External Database | Details |
---|---|---|
Met 4 | - | expression tag |
Lys 5 | - | expression tag |
Ala 57 | Arg 438 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55987.6 | |
All* | Total formula weight | 55987.6 |