3QB4

Crystal structure of a TGF-beta ligand-receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Growth/differentiation factor 5	polymer	117	13319.4	2	UniProt (P43026) Pfam (PF00019) In PDB	Homo sapiens (human)	GDF-5, Cartilage-derived morphogenetic protein 1, CDMP-1, Radotermin
2	B, D	Bone morphogenetic protein receptor type-1A	polymer	135	14674.5	2	UniProt (P36894) Pfam (PF01064) In PDB	Homo sapiens (human)	BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5
3		water	water		18.0	93	Chemie (HOH)

Sequence modifications

A, C: 6 - 120 (UniProt: P43026)

PDB	External Database	Details
Met 4	-	expression tag
Lys 5	-	expression tag
Ala 57	Arg 438	engineered mutation

B, D: 1 - 129 (UniProt: P36894)

PDB	External Database	Details
Gly -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55987.6
All*	Total formula weight	55987.6

*Water molecules are not included.