3NH7

Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA

Summary for 3NH7

• Entry DOI: 10.2210/pdb3nh7/pdb
• Related: 1REW 2K3G
• Descriptor: Antibody fragment Fab AbD1556, heavy chain, Antibody fragment Fab AbD1556, light chain, Bone morphogenetic protein receptor type-1A, ... (4 entities in total)
• Functional Keywords: antibody-antigen complex, bmp receptor extracellular domain, bone morphogenetic protein, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P36894
• Total number of polymer chains: 12
• Total formula weight: 247366.70

Authors

Mueller, T.D.,Harth, S.,Sebald, W. (deposition date: 2010-06-14, release date: 2010-10-27, Last modification date: 2023-11-01)

• Primary citation: Harth, S.,Kotzsch, A.,Hu, J.,Sebald, W.,Mueller, T.D.; A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity; Plos One, 5:e13049-e13049, 2010; PubMed: 20927405; DOI: 10.1371/journal.pone.0013049

Experimental method

X-RAY DIFFRACTION (2.7 Å)