2W6C
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![BU of 2w6c by Molmil](/molmil-images/mine/2w6c) | ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(3R)-3-ethyl-1-{9-[(3S)-3-ethyl-3-(3-hydroxyphenyl)azepan-1-yl]nonyl}azepan-3-yl]phenol, ... | 著者 | Paz, A, Xie, Q, Greenblatt, H.M, Fu, W, Tang, Y, Silman, I, Qiu, Z, Sussman, J.L. | 登録日 | 2008-12-18 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(-)-Nor-Meptazinol Derivative Reveals Disruption of the Catalytic Triad. J.Med.Chem., 52, 2009
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8KH5
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![BU of 8kh5 by Molmil](/molmil-images/mine/8kh5) | Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Nie, Y, Qiu, Z, Zheng, S, Chen, S. | 登録日 | 2023-08-21 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
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8KGK
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![BU of 8kgk by Molmil](/molmil-images/mine/8kgk) | Cryo-EM structure of the GPR61-Gs complex | 分子名称: | G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Nie, Y, Qiu, Z, Zheng, S. | 登録日 | 2023-08-19 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
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8KH4
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![BU of 8kh4 by Molmil](/molmil-images/mine/8kh4) | Cryo-EM structure of the GPR161-Gs complex | 分子名称: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Nie, Y, Qiu, Z, Zheng, S, Chen, S. | 登録日 | 2023-08-21 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
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5GMZ
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![BU of 5gmz by Molmil](/molmil-images/mine/5gmz) | Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine | 分子名称: | (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | 著者 | Xu, Z.H, Zhou, Z. | 登録日 | 2016-07-18 | 公開日 | 2016-08-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors J.Med.Chem., 59, 2016
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6LOX
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![BU of 6lox by Molmil](/molmil-images/mine/6lox) | Crystal Structure of human glutaminase with macrocyclic inhibitor | 分子名称: | (E)-15,22-Dioxa-4,11-diaza-5(2,5)-thiadiazola-10(3,6)-pyridazina-1,14(1,3)-dibenzenacyclodocosaphan-18-ene-3,12-dione, Glutaminase kidney isoform, mitochondrial | 著者 | Bian, J, Li, Z, Xu, X, Wang, J, Li, L. | 登録日 | 2020-01-07 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site. J.Med.Chem., 64, 2021
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6DJB
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![BU of 6djb by Molmil](/molmil-images/mine/6djb) | Structure of human Volume Regulated Anion Channel composed of SWELL1 (LRRC8A) | 分子名称: | Volume-regulated anion channel subunit LRRC8A | 著者 | Kefauver, J.M, Saotome, K, Pallesen, J, Cottrell, C.A, Ward, A.B, Patapoutian, A. | 登録日 | 2018-05-24 | 公開日 | 2018-08-15 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of the human volume regulated anion channel. Elife, 7, 2018
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8EQ4
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![BU of 8eq4 by Molmil](/molmil-images/mine/8eq4) | Human PAC in nanodisc at pH 4.0 with PI(4,5)P2 diC8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Ruan, Z, Lu, W. | 登録日 | 2022-10-07 | 公開日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Inhibition of the proton-activated chloride channel PAC by PIP 2. Elife, 12, 2023
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8FBL
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![BU of 8fbl by Molmil](/molmil-images/mine/8fbl) | Human PAC in nanodisc at pH 4.0 with PI(4,5)P2 diC8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Ruan, Z, Lu, W. | 登録日 | 2022-11-29 | 公開日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Inhibition of the proton-activated chloride channel PAC by PIP 2. Elife, 12, 2023
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6LB8
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![BU of 6lb8 by Molmil](/molmil-images/mine/6lb8) | Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex | 分子名称: | Calcium uptake protein 2, mitochondrial, Endolysin,Calcium uptake protein 1 | 著者 | Wu, W, Shen, Q, Zheng, J, Jia, Z. | 登録日 | 2019-11-13 | 公開日 | 2020-07-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.283 Å) | 主引用文献 | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter. Embo J., 39, 2020
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6LB7
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![BU of 6lb7 by Molmil](/molmil-images/mine/6lb7) | Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex | 分子名称: | CALCIUM ION, Calcium uptake protein 1, mitochondrial, ... | 著者 | Wu, W, Shen, Q, Zheng, J, Jia, Z. | 登録日 | 2019-11-13 | 公開日 | 2020-07-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter. Embo J., 39, 2020
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7JNA
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![BU of 7jna by Molmil](/molmil-images/mine/7jna) | |
7JNC
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![BU of 7jnc by Molmil](/molmil-images/mine/7jnc) | |
2V8L
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![BU of 2v8l by Molmil](/molmil-images/mine/2v8l) | |
2V8M
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![BU of 2v8m by Molmil](/molmil-images/mine/2v8m) | |
2VQ4
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3M8P
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![BU of 3m8p by Molmil](/molmil-images/mine/3m8p) | HIV-1 RT with NNRTI TMC-125 | 分子名称: | 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, Reverse transcriptase/ribonuclease H, p51 RT | 著者 | Harris, S.F, Villasenor, A. | 登録日 | 2010-03-18 | 公開日 | 2010-05-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20, 2010
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3M8Q
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![BU of 3m8q by Molmil](/molmil-images/mine/3m8q) | HIV-1 RT with AMINOPYRIMIDINE NNRTI | 分子名称: | 3,5-dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile, Reverse transcriptase/ribonuclease H, p51 RT | 著者 | Harris, S.F, Villasenor, A. | 登録日 | 2010-03-18 | 公開日 | 2010-05-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20, 2010
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3NBP
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![BU of 3nbp by Molmil](/molmil-images/mine/3nbp) | HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2 | 分子名称: | 4-(4-{[4-(4-cyano-2,6-dimethylphenoxy)pyrimidin-2-yl]amino}piperidin-1-yl)benzenesulfonamide, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Harris, S.F, Villasenor, A.G. | 登録日 | 2010-06-03 | 公開日 | 2010-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20, 2010
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6IIH
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![BU of 6iih by Molmil](/molmil-images/mine/6iih) | crystal structure of mitochondrial calcium uptake 2(MICU2) | 分子名称: | CALCIUM ION, Endolysin,Calcium uptake protein 2, mitochondrial | 著者 | Shen, Q, Wu, W, Zheng, J, Jia, Z. | 登録日 | 2018-10-06 | 公開日 | 2019-08-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.958 Å) | 主引用文献 | The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation. Embo Rep., 20, 2019
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3VU6
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![BU of 3vu6 by Molmil](/molmil-images/mine/3vu6) | Short peptide HIV entry inhibitor MT-SC22EK with a M-T hook | 分子名称: | MTSC22, SULFATE ION, Transmembrane protein gp41 | 著者 | Yao, X, Chong, H.H, Waltersperger, S, Wang, M.T, He, Y.X, Cui, S. | 登録日 | 2012-06-19 | 公開日 | 2012-12-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.324 Å) | 主引用文献 | Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1 Faseb J., 27, 2013
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3VGX
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![BU of 3vgx by Molmil](/molmil-images/mine/3vgx) | Structure of gp41 T21/Cp621-652 | 分子名称: | ACETIC ACID, Envelope glycoprotein gp160, GLYCEROL | 著者 | Yao, X, Waltersperger, S, Wang, M, Cui, S. | 登録日 | 2011-08-22 | 公開日 | 2012-04-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652. J.Biol.Chem., 287, 2012
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3VH7
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![BU of 3vh7 by Molmil](/molmil-images/mine/3vh7) | Structure of HIV-1 gp41 NHR/fusion inhibitor complex P21 | 分子名称: | CP32M, Envelope glycoprotein gp160, MAGNESIUM ION | 著者 | Yao, X, Waltersperger, S, Wang, M.T, Cui, S. | 登録日 | 2011-08-23 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.019 Å) | 主引用文献 | Structural basis of potent and broad HIV-1 fusion inhibitor CP32M J.Biol.Chem., 287, 2012
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3VTP
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3VGY
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![BU of 3vgy by Molmil](/molmil-images/mine/3vgy) | Structure of HIV-1 gp41 NHR/fusion inhibitor complex P321 | 分子名称: | CP32M, Envelope glycoprotein gp160, SULFATE ION | 著者 | Yao, X, Waltersperger, S, Wang, M.T, Cui, S. | 登録日 | 2011-08-22 | 公開日 | 2012-06-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.034 Å) | 主引用文献 | Structural basis of potent and broad HIV-1 fusion inhibitor CP32M J.Biol.Chem., 287, 2012
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