6LOX

Crystal Structure of human glutaminase with macrocyclic inhibitor

Summary for 6LOX

Entry DOI	10.2210/pdb6lox/pdb
Descriptor	Glutaminase kidney isoform, mitochondrial, (E)-15,22-Dioxa-4,11-diaza-5(2,5)-thiadiazola-10(3,6)-pyridazina-1,14(1,3)-dibenzenacyclodocosaphan-18-ene-3,12-dione (3 entities in total)
Functional Keywords	protein-inhibitor complex, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	236949.40
Authors	Bian, J.,Li, Z.,Xu, X.,Wang, J.,Li, L. (deposition date: 2020-01-07, release date: 2021-01-13, Last modification date: 2023-11-29)
Primary citation	Xu, X.,Wang, J.,Wang, M.,Yuan, X.,Li, L.,Zhang, C.,Huang, H.,Jing, T.,Wang, C.,Tong, C.,Zhou, L.,Meng, Y.,Xu, P.,Kou, J.,Qiu, Z.,Li, Z.,Bian, J. Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site. J.Med.Chem., 64:4588-4611, 2021 Cited by PubMed: 33792311 DOI: 10.1021/acs.jmedchem.0c02044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation