6LOX

Crystal Structure of human glutaminase with macrocyclic inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutaminase kidney isoform, mitochondrial	polymer	534	58938.0	4	UniProt (O94925) Pfam (PF17959) Pfam (PF04960) Pfam (PF12796)	Homo sapiens (Human)	GLS,K-glutaminase,L-glutamine amidohydrolase
2	E, F (A, C)	(E)-15,22-Dioxa-4,11-diaza-5(2,5)-thiadiazola-10(3,6)-pyridazina-1,14(1,3)-dibenzenacyclodocosaphan-18-ene-3,12-dione	non-polymer		598.7	2	Chemie (EN3)
3	G, H, I, J (A, B, C, D)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A, B, C, D: 71 - 598 (UniProt: O94925)

PDB	External Database	Details
His 599	-	expression tag
His 600	-	expression tag
His 601	-	expression tag
His 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	235752.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1197.4
All*	Total formula weight	236949.4

*Water molecules are not included.