5GMZ
Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine
Summary for 5GMZ
Entry DOI | 10.2210/pdb5gmz/pdb |
Descriptor | Core protein, ISOPROPYL ALCOHOL, (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, ... (6 entities in total) |
Functional Keywords | hbv, capid assembly, hap, core protein, viral protein |
Biological source | Hepatitis B virus (HBV) |
Total number of polymer chains | 6 |
Total formula weight | 109263.59 |
Authors | |
Primary citation | Qiu, Z.,Lin, X.,Zhou, M.,Liu, Y.,Zhu, W.,Chen, W.,Zhang, W.,Guo, L.,Liu, H.,Wu, G.,Huang, M.,Jiang, M.,Xu, Z.,Zhou, Z.,Qin, N.,Ren, S.,Qiu, H.,Zhong, S.,Zhang, Y.,Zhang, Y.,Wu, X.,Shi, L.,Shen, F.,Mao, Y.,Zhou, X.,Yang, W.,Wu, J.Z.,Yang, G.,Mayweg, A.V.,Shen, H.C.,Tang, G. Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors J.Med.Chem., 59:7651-7666, 2016 Cited by PubMed: 27458651DOI: 10.1021/acs.jmedchem.6b00879 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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