6CUD
 
 | | Structure of the human TRPC3 in a lipid-occupied, closed state | | Descriptor: | (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Lu, W, Du, J, Fan, C, Choi, W. | | Deposit date: | 2018-03-25 | | Release date: | 2018-05-16 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018
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6UIW
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6UIV
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6UIX
 | | Cryo-EM structure of human CALHM2 gap junction | | Descriptor: | Calcium homeostasis modulator protein 2 | | Authors: | Lu, W, Du, J, Choi, W. | | Deposit date: | 2019-10-01 | | Release date: | 2019-11-27 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The structures and gating mechanism of human calcium homeostasis modulator 2.
Nature, 576, 2019
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6WBN
 | | Cryo-EM structure of human Pannexin 1 channel N255A mutant, gap junction | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, DIACYL GLYCEROL, ... | | Authors: | Lu, W, Du, J, Ruan, Z. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-03 | | Last modified: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
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6WBM
 | | Cryo-EM structure of human Pannexin 1 channel N255A mutant | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, DIACYL GLYCEROL, ... | | Authors: | Lu, W, Du, J, Ruan, Z. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-03 | | Last modified: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
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6WBG
 | | Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7 | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Lu, W, Du, J, Ruan, Z. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-03 | | Last modified: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
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6WBF
 | | Cryo-EM structure of wild type human Pannexin 1 channel | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Lu, W, Du, J, Ruan, Z. | | Deposit date: | 2020-03-26 | | Release date: | 2020-06-03 | | Last modified: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Structures of human pannexin 1 reveal ion pathways and mechanism of gating.
Nature, 584, 2020
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3JT1
 | | Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form | | Descriptor: | Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE | | Authors: | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | | Deposit date: | 2009-09-11 | | Release date: | 2010-02-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
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3JSZ
 | | Legionella pneumophila glucosyltransferase Lgt1 N293A with UDP-Glc | | Descriptor: | MAGNESIUM ION, Putative uncharacterized protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE | | Authors: | Lu, W, Du, J, Belyi, Y, Stahl, M, Zivilikidis, T, Gerhardt, S, Aktories, K, Einsle, O. | | Deposit date: | 2009-09-11 | | Release date: | 2010-02-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila.
J.Mol.Biol., 2009
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2WRY
 | | Crystal structure of chicken cytokine interleukin 1 beta | | Descriptor: | INTERLEUKIN-1BETA | | Authors: | Lu, W.S, Cheng, C.S, Lyu, P.C, Lee, L.H, Wang, W.C, Yin, H.S. | | Deposit date: | 2009-09-03 | | Release date: | 2010-09-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structural and Functional Comparison of Cytokine Interleukin-1 Beta from Chicken and Human.
Mol.Immunol., 48, 2011
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6WBK
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6WBL
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6WBI
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7JNC
 | | cryo-EM structure of human proton-activated chloride channel PAC at pH 4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel | | Authors: | Lu, W, Ruan, R, Du, J. | | Deposit date: | 2020-08-04 | | Release date: | 2020-11-11 | | Last modified: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | Structures and pH-sensing mechanism of the proton-activated chloride channel.
Nature, 588, 2020
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7JNA
 | | Cryo-EM structure of human proton-activated chloride channel PAC at pH 8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Proton-activated chloride channel | | Authors: | Lu, W, Ruan, R, Du, J. | | Deposit date: | 2020-08-04 | | Release date: | 2020-11-11 | | Last modified: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures and pH-sensing mechanism of the proton-activated chloride channel.
Nature, 588, 2020
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5UP2
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GluN2B-specific Fab, ... | | Authors: | Lu, W, Du, J, Goehring, A, Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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5UOW
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, MK-801 and a GluN2B-specific Fab, at pH 6.5 | | Descriptor: | (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Lu, W, Du, J, Goehring, A, Gouaux, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-03-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.
Science, 355, 2017
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2ZJK
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2ZJL
 | | Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide | | Descriptor: | Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | | Authors: | Randal, M, Lam, M.B, Lu, W, Romanowski, M.J. | | Deposit date: | 2008-03-07 | | Release date: | 2009-01-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
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3GNY
 | | Crystal structure of human alpha-defensin 1 (HNP1) | | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 | | Authors: | Pazgier, M, Lu, W.-Y. | | Deposit date: | 2009-03-18 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Through the looking glass, mechanistic insights from enantiomeric human defensins.
J.Biol.Chem., 284, 2009
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3GO0
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1ZMH
 | | Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala) | | Descriptor: | GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ... | | Authors: | Lubkowski, J, Prahl, A, Lu, W. | | Deposit date: | 2005-05-10 | | Release date: | 2005-08-16 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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1ZMI
 | | Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) | | Descriptor: | GLYCEROL, Neutrophil defensin 2, SULFATE ION | | Authors: | Lubkowski, J, Prahl, A, Lu, W. | | Deposit date: | 2005-05-10 | | Release date: | 2005-08-16 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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1ZMK
 | | Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group | | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 2 | | Authors: | Lubkowski, J, Prahl, A, Lu, W. | | Deposit date: | 2005-05-10 | | Release date: | 2005-08-16 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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