6WBI

Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in complex with CBX

Summary for 6WBI

• Entry DOI: 10.2210/pdb6wbi/pdb
• EMDB information: 21588 21589 21590 21591 21592 21593 21594 21595 21596 21597 21598
• Descriptor: Pannexin-1, CARBENOXOLONE (2 entities in total)
• Functional Keywords: ion channel, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 7
• Total formula weight: 294592.36

Authors

Lu, W.,Du, J.,Ruan, Z. (deposition date: 2020-03-26, release date: 2020-06-03, Last modification date: 2020-09-09)

• Primary citation: Ruan, Z.,Orozco, I.J.,Du, J.,Lu, W.; Structures of human pannexin 1 reveal ion pathways and mechanism of gating.; Nature, 584:646-651, 2020; PubMed: 32494015; DOI: 10.1038/s41586-020-2357-y

Experimental method

ELECTRON MICROSCOPY (4.39 Å)