6WBI

Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in complex with CBX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006812	biological_process	monoatomic cation transport
A	0015267	molecular_function	channel activity
A	0032732	biological_process	positive regulation of interleukin-1 production
B	0006812	biological_process	monoatomic cation transport
B	0015267	molecular_function	channel activity
B	0032732	biological_process	positive regulation of interleukin-1 production
C	0006812	biological_process	monoatomic cation transport
C	0015267	molecular_function	channel activity
C	0032732	biological_process	positive regulation of interleukin-1 production
D	0006812	biological_process	monoatomic cation transport
D	0015267	molecular_function	channel activity
D	0032732	biological_process	positive regulation of interleukin-1 production
E	0006812	biological_process	monoatomic cation transport
E	0015267	molecular_function	channel activity
E	0032732	biological_process	positive regulation of interleukin-1 production
F	0006812	biological_process	monoatomic cation transport
F	0015267	molecular_function	channel activity
F	0032732	biological_process	positive regulation of interleukin-1 production
G	0006812	biological_process	monoatomic cation transport
G	0015267	molecular_function	channel activity
G	0032732	biological_process	positive regulation of interleukin-1 production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	896
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-CYS40
E	ARG128-ARG217
F	MET1-CYS40
F	ARG128-ARG217
G	MET1-CYS40
G	ARG128-ARG217
A	ARG128-ARG217
B	MET1-CYS40
B	ARG128-ARG217
C	MET1-CYS40
C	ARG128-ARG217
D	MET1-CYS40
D	ARG128-ARG217
E	MET1-CYS40

---

site_id	SWS_FT_FI2
Number of Residues	560
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351

Chain	Residue	Details
A	ILE41-GLY61
C	LYS107-TRP127
C	LEU218-SER238
C	LEU267-LEU287
D	ILE41-GLY61
D	LYS107-TRP127
D	LEU218-SER238
D	LEU267-LEU287
E	ILE41-GLY61
E	LYS107-TRP127
E	LEU218-SER238
A	LYS107-TRP127
E	LEU267-LEU287
F	ILE41-GLY61
F	LYS107-TRP127
F	LEU218-SER238
F	LEU267-LEU287
G	ILE41-GLY61
G	LYS107-TRP127
G	LEU218-SER238
G	LEU267-LEU287
A	LEU218-SER238
A	LEU267-LEU287
B	ILE41-GLY61
B	LYS107-TRP127
B	LEU218-SER238
B	LEU267-LEU287
C	ILE41-GLY61

---

site_id	SWS_FT_FI3
Number of Residues	497
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	THR62-HIS106
E	SER239-LYS266
F	THR62-HIS106
F	SER239-LYS266
G	THR62-HIS106
G	SER239-LYS266
A	SER239-LYS266
B	THR62-HIS106
B	SER239-LYS266
C	THR62-HIS106
C	SER239-LYS266
D	THR62-HIS106
D	SER239-LYS266
E	THR62-HIS106

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9JIP4

Chain	Residue	Details
A	CYS40
E	CYS347
F	CYS40
F	CYS347
G	CYS40
G	CYS347
A	CYS347
B	CYS40
B	CYS347
C	CYS40
C	CYS347
D	CYS40
D	CYS347
E	CYS40

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30814251

Chain	Residue	Details
A	TYR199
B	TYR199
C	TYR199
D	TYR199
E	TYR199
F	TYR199
G	TYR199

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17715132, ECO:0000269|PubMed:30918116, ECO:0000269|PubMed:32494015, ECO:0000269|PubMed:33947837

Chain	Residue	Details
A	ASN255
B	ASN255
C	ASN255
D	ASN255
E	ASN255
F	ASN255
G	ASN255

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