5UP2

Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5

Summary for 5UP2

• Entry DOI: 10.2210/pdb5up2/pdb
• Related: 5UOW
• EMDB information: 8579 8581
• Descriptor: N-methyl-D-aspartate receptor subunit NR1-8a, N-methyl-D-aspartate receptor subunit NR2A, Ionotropic glutamate receptor subunit NR2B, ... (6 entities in total)
• Functional Keywords: membrane protein
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 6
• Total formula weight: 414921.23

Authors

Lu, W.,Du, J.,Goehring, A.,Gouaux, E. (deposition date: 2017-02-01, release date: 2017-03-22, Last modification date: 2020-07-29)

• Primary citation: Lu, W.,Du, J.,Goehring, A.,Gouaux, E.; Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.; Science, 355:-, 2017; PubMed: 28232581; DOI: 10.1126/science.aal3729

Experimental method

ELECTRON MICROSCOPY (6 Å)