5UP2
Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 704 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| D | GLN25-MET554 | |
| D | ALA644-ALA819 | |
| C | GLY21-GLN557 | |
| C | THR646-ASN810 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| D | MET555-PHE573 | |
| D | TRP628-LEU643 | |
| B | PHE809-PHE829 | |
| C | SER558-LEU578 | |
| C | ILE629-TYR645 | |
| C | MET811-ILE831 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| D | SER574-TRP600 | |
| D | SER621-VAL627 | |
| C | ASP579-THR600 | |
| C | ARG623-ARG628 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| D | LEU601-THR620 | |
| C | LEU601-PRO622 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | HIS120 | |
| B | ASP274 | |
| B | ASN503 | |
| B | VAL510 | |
| B | ASN681 | |
| B | VAL722 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:25008524 |
| Chain | Residue | Details |
| D | GLU511 | |
| B | ASN332 | |
| B | ALA372 | |
| B | THR435 | |
| B | GLU436 | |
| B | SER533 | |
| B | GLU679 | |
| C | ASP730 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| D | VAL516 | |
| D | LEU729 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| D | ASN687 | |
| C | ASN203 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLL, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2 |
| Chain | Residue | Details |
| D | ASN336 | |
| C | ASN276 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLM, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2 |
| Chain | Residue | Details |
| D | GLU685 | |
| C | GLN300 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | GLN350 | |
| C | GLU769 | |
| A | ASP440 | |
| A | ASP469 | |
| A | ASN489 | |
| A | GLU769 | |
| C | GLN350 | |
| C | ASP440 | |
| C | ASP469 | |
| C | ASN489 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677647, ECO:0007744|PDB:3QEK, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM |
| Chain | Residue | Details |
| A | ASP368 | |
| C | ASP368 |
