Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5UP2

Triheteromeric NMDA receptor GluN1/GluN2A/GluN2B in complex with glycine, glutamate, Ro 25-6981, MK-801 and a GluN2B-specific Fab, at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	145
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	61
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	328
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	57
Details	Region: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P35439","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27916457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27916457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	17
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	59
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	19
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	170
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	21
Details	Region: {"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00959","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	175
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	19
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"Q00960","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00960","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)