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2ZJL

Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide

Summary for 2ZJL
Entry DOI10.2210/pdb2zjl/pdb
Related2ZJH 2ZJI 2ZJJ 2ZJK 2ZJM 2ZJN
DescriptorBeta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (3 entities in total)
Functional Keywordsbace1, small-molecule inhibitor, tethering, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight45674.29
Authors
Randal, M.,Lam, M.B.,Lu, W.,Romanowski, M.J. (deposition date: 2008-03-07, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citationYang, W.,Fucini, R.V.,Fahr, B.T.,Randal, M.,Lind, K.E.,Lam, M.B.,Lu, W.,Lu, Y.,Cary, D.R.,Romanowski, M.J.
Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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