2ZJL
Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide
Summary for 2ZJL
Entry DOI | 10.2210/pdb2zjl/pdb |
Related | 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJM 2ZJN |
Descriptor | Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (3 entities in total) |
Functional Keywords | bace1, small-molecule inhibitor, tethering, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, protease, transmembrane, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45674.29 |
Authors | Randal, M.,Lam, M.B.,Lu, W.,Romanowski, M.J. (deposition date: 2008-03-07, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Yang, W.,Fucini, R.V.,Fahr, B.T.,Randal, M.,Lind, K.E.,Lam, M.B.,Lu, W.,Lu, Y.,Cary, D.R.,Romanowski, M.J. Fragment-based discovery of novel BACE1 inhibitors using Tethering technology To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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