3VU6

Short peptide HIV entry inhibitor MT-SC22EK with a M-T hook

Summary for 3VU6

• Entry DOI: 10.2210/pdb3vu6/pdb
• Related: 1env 3VU5 3vgx
• Descriptor: Transmembrane protein gp41, MTSC22, SULFATE ION, ... (4 entities in total)
• Functional Keywords: 6-helix bundle, coiled-coil, membrane, fusion inhibitor, m-t hook, hiv entry, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P03375
• Total number of polymer chains: 2
• Total formula weight: 7702.92

Authors

Yao, X.,Chong, H.H.,Waltersperger, S.,Wang, M.T.,He, Y.X.,Cui, S. (deposition date: 2012-06-19, release date: 2012-12-19, Last modification date: 2023-11-08)

• Primary citation: Chong, H.H.,Yao, X.,Qiu, Z.,Sun, J.,Zhang, M.,Waltersperger, S.,Wang, M.T.,Liu, S.-L.,Cui, S.,He, Y.X.; Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1; Faseb J., 27:1203-1213, 2013; PubMed: 23233535; DOI: 10.1096/fj.12-222547

Experimental method

X-RAY DIFFRACTION (2.324 Å)