3VTP

HIV fusion inhibitor MT-C34

Summary for 3VTP

• Entry DOI: 10.2210/pdb3vtp/pdb
• Related: 3VGX 3VIE 3VTQ
• Descriptor: Transmembrane protein gp41 (3 entities in total)
• Functional Keywords: 6-helix-bundle, m-t hook, fusion inhibitor, membrane fusion, viral protein-antiviral protein complex, viral protein/antiviral protein
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P03377 P03377
• Total number of polymer chains: 2
• Total formula weight: 9407.60

Authors

Yao, X.,Waltersperger, S.,Wang, M.,Cui, S. (deposition date: 2012-06-02, release date: 2012-08-22, Last modification date: 2023-11-08)

• Primary citation: Chong, H.,Yao, X.,Sun, J.,Qiu, Z.,Zhang, M.,Waltersperger, S.,Wang, M.,Cui, S.,He, Y.; The M-T hook structure is critical for design of HIV-1 fusion inhibitors.; J.Biol.Chem., 287:34558-34568, 2012; PubMed: 22879603; DOI: 10.1074/jbc.M112.390393

Experimental method

X-RAY DIFFRACTION (1.9 Å)