3M8P

HIV-1 RT with NNRTI TMC-125

Summary for 3M8P

• Entry DOI: 10.2210/pdb3m8p/pdb
• Related: 2ZD1
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, ... (4 entities in total)
• Functional Keywords: hiv, rt, reverse transcriptase ribonuclease h, transferase rna-directed dna polymerase, nucleotidyltransferase, hydrolase, transferase
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116544.45

Authors

Harris, S.F.,Villasenor, A. (deposition date: 2010-03-18, release date: 2010-05-19, Last modification date: 2024-02-21)

• Primary citation: Kertesz, D.J.,Brotherton-Pleiss, C.,Yang, M.,Wang, Z.,Lin, X.,Qiu, Z.,Hirschfeld, D.R.,Gleason, S.,Mirzadegan, T.,Dunten, P.W.,Harris, S.F.,Villasenor, A.G.,Hang, J.Q.,Heilek, G.M.,Klumpp, K.; Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.; Bioorg.Med.Chem.Lett., 20:4215-4218, 2010; PubMed: 20538456; DOI: 10.1016/j.bmcl.2010.05.040

Experimental method

X-RAY DIFFRACTION (2.67 Å)