3NBP

HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2

Summary for 3NBP

• Entry DOI: 10.2210/pdb3nbp/pdb
• Related: 3M8P 3M8Q
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: hiv, rt, reverse transcriptase, transferase rna-directed dna polymerase, nucleotidyltransferase, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116697.61

Authors

Harris, S.F.,Villasenor, A.G. (deposition date: 2010-06-03, release date: 2010-08-18, Last modification date: 2024-02-21)

Primary citation

Kertesz, D.J.,Brotherton-Pleiss, C.,Yang, M.,Wang, Z.,Lin, X.,Qiu, Z.,Hirschfeld, D.R.,Gleason, S.,Mirzadegan, T.,Dunten, P.W.,Harris, S.F.,Villasenor, A.G.,Hang, J.Q.,Heilek, G.M.,Klumpp, K.
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg.Med.Chem.Lett., 20:4215-4218, 2010

PubMed Abstract: An analysis of the binding motifs of known HIV-1 non-nucleoside reverse transcriptase inhibitors has led to discovery of novel piperidine-linked aminopyrimidine derivatives with broad activity against wild-type as well as drug-resistant mutant viruses. Notably, the series retains potency against the K103N/Y181C and Y188L mutants, among others. Thus, the N-benzyl compound 5k has a particularly attractive profile. Synthesis and SAR are presented and discussed, as well as crystal structures relating to the binding motifs.

PubMed: 20538456
DOI: 10.1016/j.bmcl.2010.05.040

Experimental method

X-RAY DIFFRACTION (2.95 Å)