3M8Q

HIV-1 RT with AMINOPYRIMIDINE NNRTI

Summary for 3M8Q
Related3M8P
DescriptorReverse transcriptase/ribonuclease H, p51 RT, 3,5-dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile, ... (4 entities in total)
Functional Keywordshiv, rt, reverse transcriptase ribonuclease h, transferase rna-directed dna polymerase, nucleotidyltransferase, hydrolase, transferase
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116600.77
Authors
Harris, S.F.,Villasenor, A. (deposition date: 2010-03-18, release date: 2010-05-19, Last modification date: 2011-07-13)
Primary citationBrotherton-Pleiss, C.,Dunten, P.W.,Gleason, S.,Hang, J.Q.,Harris, S.F.,Heilek, G.M.,Hirschfeld, D.R.,Kertesz, D.J.,Klumpp, K.,Lin, X.,Mirzadegan, T.,Qiu, Z.,Villasenor, A.G.,Wang, Z.,Yang, M.
Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg.Med.Chem.Lett., 20:4215-4218, 2010
PubMed: 20538456
DOI: 110.1016/j.bmcl.2010.05.040
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB Foundation
wwPDBRCSB PDBPDBeBMRBAdv. SearchSearch help

178938

PDB entries from 2021-06-16