Structure of gp41 T21/Cp621-652

Summary for 3VGX

Related3VGY 3VH7
DescriptorEnvelope glycoprotein gp160, ACETIC ACID, GLYCEROL, ... (5 entities in total)
Functional Keywords6-helix bundle, membrane fusion, membrane protein
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationTransmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein P03375 P03375
Total number of polymer chains2
Total molecular weight8693.82
Yao, X.,Waltersperger, S.,Wang, M.,Cui, S. (deposition date: 2011-08-22, release date: 2012-04-25, Last modification date: 2013-06-26)
Primary citation
Chong, H.,Yao, X.,Qiu, Z.,Qin, B.,Han, R.,Waltersperger, S.,Wang, M.,Cui, S.,He, Y.
Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652.
J.Biol.Chem., 287:20281-20289, 2012
PubMed: 22511760 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.354126
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.194503.3%12.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution