4WIV
| Crystal Structure of the first bromodomain of human BRD4 in complex with a novel inhibitor UMB32 (N-TERT-BUTYL-2-[4-(3,5-DIMETHYL-1,2-OXAZOL-4-YL) PHENYL]IMIDAZO[1,2-A]PYRAZIN-3-AMINE) | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... | Authors: | Xu, X, Blacklow, S. | Deposit date: | 2014-09-26 | Release date: | 2014-10-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Biased multicomponent reactions to develop novel bromodomain inhibitors. J.Med.Chem., 57, 2014
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4WVL
| Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Histone-lysine N-methyltransferase, ... | Authors: | Xu, X, Dhe-Paganon, S, Blacklow, S. | Deposit date: | 2014-11-06 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement. Acs Chem.Biol., 10, 2015
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4Y2W
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8AN4
| MenT1 toxin (rv0078a) from Mycobacterium tuberculosis H37Rv | Descriptor: | Bacterial toxin | Authors: | Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P. | Deposit date: | 2022-08-04 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding. Nat Commun, 14, 2023
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8AN5
| MenAT1 toxin-antitoxin complex (rv0078a-rv0078b) from Mycobacterium tuberculosis H37Rv | Descriptor: | Bacterial toxin, Conserved protein | Authors: | Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P. | Deposit date: | 2022-08-04 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding. Nat Commun, 14, 2023
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8X2J
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5M82
| Three-dimensional structure of the photoproduct state of GAF3 from Slr1393 of Synechocystis sp. PCC6803 | Descriptor: | (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, PHYCOCYANOBILIN, SODIUM ION, ... | Authors: | Xu, X.-L, Zhao, K.-H, Gaertner, W, Hoeppner, A. | Deposit date: | 2016-10-28 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural elements regulating the photochromicity in a cyanobacteriochrome Proc.Natl.Acad.Sci.USA, 2020
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5M85
| Three-dimensional structure of the intermediate state of GAF3 from Slr1393 of Synechocystis sp. PCC6803 | Descriptor: | (2S)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHYCOCYANOBILIN, ... | Authors: | Xu, X.-L, Zhao, K.-H, Gaertner, W, Hoeppner, A. | Deposit date: | 2016-10-28 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural elements regulating the photochromicity in a cyanobacteriochrome Proc.Natl.Acad.Sci.USA, 2020
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7S0R
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3VCB
| C425S mutant of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59 | Descriptor: | RNA-directed RNA polymerase | Authors: | Xu, X, Lou, Z, Ma, Y, Chen, X, Yang, Z, Tong, X, Zhao, Q, Xu, Y, Deng, H, Bartlam, M, Rao, Z. | Deposit date: | 2012-01-03 | Release date: | 2012-01-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. Plos One, 4, 2009
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3VC8
| Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59 | Descriptor: | RNA-directed RNA polymerase | Authors: | Xu, X, Lou, Z, Ma, Y, Chen, X, Yang, Z, Tong, X, Zhao, Q, Xu, Y, Deng, H, Bartlam, M, Rao, Z. | Deposit date: | 2012-01-03 | Release date: | 2012-01-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. Plos One, 4, 2009
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6UWT
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6UWR
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6WVT
| Structural basis of alphaE-catenin - F-actin catch bond behavior | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Xu, X.P, Pokutta, S, Torres, M, Swift, M.F, Hanein, D, Volkmann, N, Weis, W.I. | Deposit date: | 2020-05-06 | Release date: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Structural basis of alpha E-catenin-F-actin catch bond behavior. Elife, 9, 2020
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8XOP
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4ZLP
| Crystal Structure of Notch3 Negative Regulatory Region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2015-05-01 | Release date: | 2015-08-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.479 Å) | Cite: | Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
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5GS6
| Full-length NS1 structure of Zika virus from 2015 Brazil strain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NS1 of Zika virus from 2015 Brazil strain | Authors: | Xu, X.Y, Song, H, Qi, J.X, Shi, Y, Gao, G.F. | Deposit date: | 2016-08-14 | Release date: | 2016-10-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.852 Å) | Cite: | Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure Embo J., 35, 2016
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8XOO
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8XON
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2GTH
| crystal structure of the wildtype MHV coronavirus non-structural protein nsp15 | Descriptor: | Replicase polyprotein 1ab | Authors: | Xu, X, Zhai, Y, Sun, F, Lou, Z, Su, D, Rao, Z. | Deposit date: | 2006-04-28 | Release date: | 2006-08-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15 J.Virol., 80, 2006
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2GTI
| mutation of MHV coronavirus non-structural protein nsp15 (F307L) | Descriptor: | GLYCEROL, Replicase polyprotein 1ab, SULFATE ION | Authors: | Xu, X, Zhai, Y, Sun, F, Lou, Z, Su, D, Rao, Z. | Deposit date: | 2006-04-28 | Release date: | 2006-08-15 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15 J.Virol., 80, 2006
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4ZSO
| Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... | Authors: | Xu, X, Li, Y, Mariuzza, R.A. | Deposit date: | 2015-05-13 | Release date: | 2016-05-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody to be published
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4OIV
| Structural basis for small molecule NDB as a selective antagonist of FXR | Descriptor: | Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide | Authors: | Xu, X, Chen, L, Hu, L, Shen, X. | Deposit date: | 2014-01-20 | Release date: | 2015-03-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor. J.Biol.Chem., 290, 2015
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8GXC
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8GXB
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