2GTH

crystal structure of the wildtype MHV coronavirus non-structural protein nsp15

Summary for 2GTH

• Entry DOI: 10.2210/pdb2gth/pdb
• Descriptor: Replicase polyprotein 1ab (2 entities in total)
• Functional Keywords: mhv, nsp15, viral protein
• Biological source: Murine hepatitis virus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P16342
• Total number of polymer chains: 1
• Total formula weight: 41697.20

Authors

Xu, X.,Zhai, Y.,Sun, F.,Lou, Z.,Su, D.,Rao, Z. (deposition date: 2006-04-28, release date: 2006-08-15, Last modification date: 2023-10-25)

• Primary citation: Xu, X.,Zhai, Y.,Sun, F.,Lou, Z.,Su, D.,Xu, Y.,Zhang, R.,Joachimiak, A.,Zhang, X.C.,Bartlam, M.,Rao, Z.; New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15; J.Virol., 80:7909-7917, 2006; PubMed: 16873248; DOI: 10.1128/JVI.00525-06

Experimental method

X-RAY DIFFRACTION (2.7 Å)